CLEVELAND — Max Kepler hit two more home runs off Trevor Bauer, Jake Cave drove in three runs and the Minnesota Twins tightened their grip on the AL Central with a 6-2 win Saturday night over the Cleveland Indians, who have slipped two games further back this weekend.

Kepler homered leading off the game and again in the second inning off Bauer (8-7), giving the Twins outfielder five homers in five consecutive at-bats — all in Cleveland — over two games against the right-hander. Kepler homered three times off Bauer on June 6.

Jake Odorizzi (11-4) didn’t get to pitch in Tuesday’s All-Star Game at Progressive Field because of a blister on his middle finger. But he came off the injured list and held the Indians to one run in 5 1/3 innings.

By winning the first two games of the series, the Twins have moved 7½ games ahead of the Indians, who knocked six off Minnesota’s lead in the weeks leading into the break.

Cubs 10, Pirates 4: Jon Lester homered, tied a career high with three RBIs and pitched effectively into the seventh inning to lead Chicago past visiting Pittsburgh.

All-Star catcher Willson Contreras’ three-run homer and Lester’s two-run single off the left-field wall were the big hits in the Cubs’ seven-run first inning.

The 35-year-old left-hander connected for his third career home run — all with the Cubs at Wrigley Field — for the NL Central leaders.

Lester (9-6) allowed three runs on eight hits. He struck out six and walked none in 6 2/3 innings.

Addison Russell drove in two runs for the Cubs.

Orioles 2-4, Rays 1-12: Michael Brosseau and Nate Lowe each hit two of Tampa Bay’s season-high six home runs, and the visiting Rays pounded Baltimore to earn a doubleheader split.

Brosseau hit a two-run drive in the second inning and a solo shot in the ninth. Lowe went deep with a man on in the sixth and the ninth. It was the first career multihomer game for both players.

Yandy Diaz and Tommy Pham also homered for the Rays, who have won four of five to move within six games of the first-place Yankees in the AL East.

In the opener of the split doubleheader, Stevie Wilkerson hit a two-run homer to back an effective pitching performance by the Orioles.

Blue Jays 2, Yankees 1: Toronto center fielder Randal Grichuk made a diving catch with the bases loaded and hit a two-run single as the Blue Jays earned a road win over New York.

The AL East-leading Yankees, who have not been shut out in more than a year, scored with two outs in the ninth inning on Aaron Judge’s fourth hit of the game, a single off third baseman Brandon Drury’s glove.

With runners at the corners, Luke Voit looked at strike three from Daniel Hudson to end it. Hudson posted his second save while Voit went 0 for 3 with two walks after being activated from the injured list.

Joe Biagini (3-1) got one out, allowing a hit and walk, and picked up the win. Toronto starter Clayton Richard left after two innings with left lat tightness, and five relievers followed.

Grichuk’s bloop single came in the sixth after the Blue Jays put two on against starter J.A. Happ (7-5). Adam Ottavino relieved and struck out Vladimir Guerrero Jr., and a double steal set up Grichuk’s hit.

Biagini relieved with two outs in the fifth, and a single by Judge and a walk to Voit loaded the bases. Gary Sanchez hit a liner up the middle and Grichuk rushed in to make a diving catch.

Cardinals 4, Diamondbacks 2: Tyler O’Neill homered and tied a career high with four RBIs, Dakota Hudson pitched six effective innings, and St. Louis beat visiting Arizona. The Cardinals broke a three-game losing streak with their first win since July 5.

Eduardo Escobar hit his 19th homer for Arizona, which snapped a four-game win streak.

O’Neill, recalled from Triple-A Memphis on June 29, also drove in four runs in a 6-0 win over Kansas City on May 21, 2018.

Athletics 13, White Sox 2: Franklin Barreto hit a three-run home run to cap a seven-run first inning, and Oakland routed visiting Chicago.

Matt Chapman had three hits and scored twice for the A’s, who have won nine of 11. Marcus Semien added two hits and Robbie Grossman drove in three runs.

Chris Bassitt (6-4) pitched six scoreless innings and struck out six.

Semien and Chapman started Oakland’s early barrage with back-to-back doubles off Dylan Covey (1-5). After Matt Olson and Khris Davis walked, Grossman’s two-run single made it 3-0.

Chris Herrmann added an RBI single to chase Covey before Barreto homered off former A’s reliever Ross Detwiler.

Royals 4, Tigers 1: Hometown boy Bubba Starling delivered his first career hit and RBI for Kansas City, Brad Keller outdueled Matthew Boyd, and the Royals held on to beat visiting Detroit.

Keller (5-9) allowed an RBI single to Harold Castro in the second but otherwise shut down Detroit, allowing four hits over eight innings. He struck out seven without a walk after entering the game having allowed the second-most free passes in the American League this season.

Ian Kennedy worked the ninth to earn his second save in as many nights.

Mets 4, Marlins 2: Robinson Cano hit a tiebreaking, two-run homer in the eighth inning to lift New York to a road victory over Miami.

Cano’s fifth home run of the season sailed into the second deck in right field at Marlins Park, breaking a 2-all tie.

Noah Syndergaard (7-4) won his fourth consecutive decision.

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