PARIS — World No. 1 Naomi Osaka’s winning streak at the majors ended in a third-round defeat at the French Open on Saturday, while on the men’s side, top-ranked Novak Djokovic extended his victorious run to 24 in search of a second career non-calendar year Grand Slam.

Osaka fell 6-4, 6-2 against 42nd-ranked Katerina Siniakova as the heavily depleted women’s field saw another shocking exit.

Osaka has never gone beyond the third round in four appearances at Roland Garros. She had won 16 straight Grand Slam matches in a row before, with titles at the 2018 U.S. Open and the Australian Open in January.

The women’s field was further depleted when No. 10 Serena Williams lost 6-2, 7-5 against Sofia Kenin, ending another bid for a record-tying 24th Grand Slam title.

But third-seeded title holder Simona Halep made short work of 27th seed Lesia Tsurenko, 6-2, 6-1.

Djokovic, meanwhile, won 6-3, 6-3, 6-2 over qualifier Salvatore Caruso.

Djokovic is bidding to hold all four Grand Slam titles at the same time for the second time in his career, as in 2015-16. He won Wimbledon and the U.S. Open last year, plus the Australian Open in January.

Fourth-seed Dominic Thiem, the 2018 runner-up, beat Pablo Cuevas 6-3, 4-6, 6-2, 7-5; and fifth-seed Alexander Zverev played yet another Paris five-setter as he outlasted Dusan Lajovic, 6-4, 6-2, 4-6, 1-6, 6-2.

Osaka had labored to three-set victories in her first two matches on clay, her least favorite surface, but finally ran out of luck against Siniakova.

Siniakova advanced to her first singles fourth round at the majors, but she won the Roland Garros and Wimbledon doubles titles last year with compatriot Barbora Krejcikova, and is the current doubles world No. 1.

Siniakova, 23, broke Osaka in the 10th game and twice more in the second set, wrapping up matters on the first match point when Osaka committed her 38th unforced error by hitting a forehand long.

Siniakova had only 13 errors in her biggest career win in 1 hour, 17 minutes.

Osaka said the pressure of being No. 1 and winning the last Grand Slams affected her.

“Clay is one of the Grand Slams, and I have to figure out how to sort of embrace it and love it in my own way,” Osaka said. “I mean, when I get here, I’m excited, I guess. But then it kind of goes away, because I try to focus on playing my matches.”

Despite the defeat, Osaka will retain the top ranking after Paris because all four rivals who could have overtaken her are not in the tournament any longer.

The highest women’s seeds are now Halep and seventh-ranked Sloane Stephens, a 2018 finalist.

Halep, 27, struggled a little with her serve in the first set, but was never seriously tested in a 6-2, 6-1 triumph over Tsurenko.

“Before the match, I was really nervous,” Halep said. “I have to admit big emotions, but it’s normal. I’m here again. I’m feeling good, and I have expectations for myself to play good tennis.”

The 37-year-old Williams has not won a Grand Slam since being pregnant at the 2017 Australian Open and slumped to her worst result at the majors since 2014 Wimbledon.

The 23-year-old, who won her first career title in January in Hobart, prevailed in 1 hour, 32 minutes for her biggest career success when Williams hit a groundstroke long.

“I’m just pretty far away, but the optimistic part is I haven’t been able to be on the court as much as I would have,” said Williams, who has rarely played this year owing to knee problems.

Djokovic made short work of 147th-ranked Caruso, who was playing at Roland Garros for the first time, firing eight aces and 25 winners en route to victory in 2 hours 4 minutes.

He next meets 45th-ranked Jan-Lennard Struff, who stunned 13th seed Borna Coric 4-6, 6-1, 4-6, 7-6 (7-1), 11-9.

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