HOUSTON — Aaron Sanchez looked like a reinvented pitcher in his Houston debut, throwing six stellar innings to start the Astros on a combined no-hitter Saturday night in a 9-0 victory over the Seattle Mariners.

Sanchez was an All-Star in 2016 and led the American League in ERA, but he’s struggled this season and had lost 13 straight decisions to lead the majors with 14 losses. But three days after he was acquired from Toronto at the trade deadline, the 27-year-old right-hander teamed with Will Harris, Joe Biagini and Chris Devenski to shut down the Mariners.

It was the second time in less than a month the Mariners were no-hit by multiple pitchers. The Angels used two pitchers in a combined no-hitter July 12 against Seattle on a night when they honored late left-hander Tyler Skaggs by all wearing his No. 45 in their first home game since his death.

Yankees 9, Red Sox 2: Fueled by a seven-run fourth inning against Chris Sale, New York ran to a Saturday afternoon victory against Boston.

Since taking the first three games of a four-game series at Fenway Park, the Red Sox have now dropped six straight games and plunged to 12§ games behind the AL East-leading Yanks.

Domingo German (14-2) lasted seven innings and gave up just two solo homers, to Andrew Benintendi (second inning) and former Prince George High School standout Jackie Bradley Jr. (fifth inning). German struck out seven.

It was a 1-1 game going into the fourth when the Yankees rallied with six-straight two-out hits.

D.J. LeMahieu clubbed his second homer of the day, a three-run shot to right field.

Aaron Judge doubled to chase Sale, who was charged with eight runs on nine hits in 3⅔ innings, with no walks and four strikeouts.

Cubs 4, Brewers 1: Albert Almora Jr.’s tiebreaking line-drive into the left-field basket at Wrigley Field in the seventh inning propelled Chicago to a win over Milwaukee.

Cole Hamels pitched five shutout innings in his first start since going on the injured list with an oblique strain on June 29. He struck out six while yielding four hits and no walks in a 74-pitch outing.

After reliever Rowan Wick (1-1) escaped a jam in the top of the seventh, Almora hit a one-out homer off Junior Guerra (3-3) to snap a 1-1 tie. The Cubs added a pair in the eighth against Freddy Peralta on Javier Baez’s RBI single and Almora’s sacrifice fly.

Closer Craig Kimbrel, the sixth Cubs reliever, pitched a scoreless ninth for his ninth save.

Rays 8, Marlins 6: Eric Sogard homered twice and finished with a career-high five RBIs, and Tampa Bay beat Miami.

Willy Adames and Austin Meadows also connected as Tampa Bay won for the seventh time in eight games. Nick Anderson (3-4), who was acquired in a trade with Miami on Wednesday, pitched a perfect eighth for the win, and Emilio Pagan finished for his ninth save.

The Rays went ahead to stay on Adames’ leadoff drive against Jarlin Garcia (2-1) in the eighth. Travis d’Arnaud, who has 26 RBIs since July 1, made it 8-6 with a run-scoring single later in the inning.

Sogard, picked up in a trade with Toronto on Sunday, hit a two-run shot in the second and a three-run drive off Elieser Hernandez in the third.

Starlin Castro homered for Miami, which has dropped three of four.

Indians 7, Angels 2: Francisco Lindor and Jason Kipnis homered during a five-run fifth inning that propelled Cleveland to a win over Los Angeles.

Kipnis hit a two-run homer off Trevor Cahill (3-7), who replaced injured starter Félix Peña in the second. Lindor’s three-run drive was off Justin Anderson. Carlos Santana hit his team-leading 24th homer off Cam Bedrosian.

Cleveland right-hander Adam Plutko (4-2) allowed one run in 5ß innings.

Justin Upton had an RBI single in the eighth, but Adam Cimber struck out Kole Calhoun with two on to end the inning.

Franmil Reyes, who was acquired in a three-team trade Wednesday, lined a one-out double to left in the fifth for the Indians’ first hit. Kipnis homered to right, his 10th of the season.

Orioles 6, Blue Jays 4: Trey Mancini homered and drove in four runs and Jonathan Villar also went deep to lead Baltimore past Toronto.

After the Blue Jays pulled even with two runs in the top of the seventh, the Orioles restored their lead in the bottom half. The first two batters reached against Buddy Boshers (0-1) before Hanser Alberto hit an RBI single off Justin Shafer and Mancini added a run-scoring groundout.

Freddy Galvis and Reese McGuire homered for the Blue Jays and Vladimir Guerrero Jr. had three hits and an RBI.

Held hitless by Thomas Pannone through four innings, Baltimore took its first lead of the series with a four-run fifth. Villar homered to left, Stevie Wilkerson and Hanser Alberto singled and Mancini sent a drive into the center-field seats for his team-leading 26th home run.

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